Weight Loss Trifecta: Your Metabolism in Synergy

Weight Loss Trifecta: Your Metabolism in Synergy

Dr. Casey Greene, PharmD, IFMCP

Weight Loss Trifecta: Your Metabolism in Synergy

People often ask me what supplements I recommend for weight loss. While there’s no shortage of options out there, most fall short on the science and results part. And while I wish there was a single, magical ingredient, that’s unfortunately not the case (although each of these 3 are quite powerful). The synergy between these 3 ingredients is so powerful though that I’ve come to call them the “Weight Loss Trifecta”. 

The Weight Loss Trifecta represents 3 naturally derived ingredients that perfectly complement each other to support your metabolism, energy, and overall wellness. Imagine combining their strengths to take your health to the next level. Let’s get to know each one.

1. Berberine: The Metabolic Booster

What is Berberine?

Imagine a plant compound with centuries of history that’s been revered in traditional wellness practices across the world. That’s berberine! Found in plants like barberry and goldenseal, berberine has caught the attention of modern scientists for its role in supporting metabolic health.

Why is Berberine a Game Changer?

Berberine is like a personal trainer for your cells. It’s been researched for its potential ability to help your body handle glucose and fats more efficiently—important factors for keeping your metabolism humming. Some studies suggest berberine may support healthy blood sugar levels and even help your cells use energy more effectively. Ready to turn up the heat on your metabolism? Berberine might just be your new best friend.

The Science Behind Berberine

In studies, people taking berberine saw promising results. Participants experienced changes in body mass index (BMI) and improvements in certain metabolic markers. It’s been shown to support an optimal microbiome for weight management, and even have GLP1 activity. The key takeaway? While results may vary, berberine has the potential to be a valuable tool in your wellness routine—especially when paired with our next 2 options. 



2. Alpha Lipoic Acid: The Energy Enhancer

What is Alpha Lipoic Acid?

Alpha lipoic acid (ALA) is an antioxidant powerhouse that your body produces naturally, but you can also find it in foods like spinach and broccoli. If your cells had a VIP guest list, ALA would be right at the top. Why? It plays a major role in converting the food you eat into energy—fueling your body for the day ahead!

How Alpha Lipoic Acid Might Supercharge Your Health

ALA’s secret weapon is its antioxidant properties. Not only does it help neutralize free radicals (the bad guys that can cause cell damage), but it also supports the body’s ability to use glucose for energy. Some studies suggest ALA may help promote healthy blood sugar levels within a normal range, which is key to managing weight and energy levels. Who wouldn’t want to boost their energy while supporting metabolic health?

What the Research Says About ALA

Research into alpha lipoic acid is full of interesting possibilities. In some studies, participants experienced changes in body composition and insulin sensitivity after incorporating ALA. Though everyone’s experience is different, ALA’s ability to support healthy metabolism is gaining attention. It might just be the ingredient that helps you feel more energized and balanced.


3. White Mulberry Leaf Extract: The Blood Sugar Balancer

What is White Mulberry Leaf Extract?

White mulberry leaf extract may sound like something straight out of a wellness fairy tale, but it’s rooted in centuries of traditional use. Derived from the white mulberry tree, this extract has been used for years to support overall health, particularly when it comes to blood sugar balance.

How Might White Mulberry Leaf Extract Support Your Journey?

White mulberry leaf extract may help keep your blood sugar levels in check. It contains natural compounds that can reduce the breakdown of carbohydrates into glucose, meaning you’re less likely to experience spikes in blood sugar. For those looking to curb sugar cravings and stabilize energy, this could be a key player in your supplement routine.

The Research on White Mulberry Leaf Extract

Some research suggests that white mulberry leaf extract may help support healthy blood sugar levels. In fact, the study on our Reductose form of white mulberry leaf extract showed a 42% reduction in blood sugar post meal compared to placebo. That’s a lot less excess blood sugar that can be converted to fat. 


The Power of Three: How the Weight Loss Trifecta Works Together

Here’s where things get exciting—berberine, alpha lipoic acid, and white mulberry leaf extract are like three superheroes, each with their own strengths, coming together to create something greater than the sum of their parts. Here’s how:

  • Blood Sugar Support: Both berberine and white mulberry leaf extract are being studied for their potential ability to support healthy blood sugar levels, which is a critical part of metabolic health.
  • Insulin Sensitivity: Berberine and alpha lipoic acid have both shown promise in research for supporting how your body responds to insulin, which plays a key role in how your body processes food and stores energy.
  • Energy Production: Alpha lipoic acid helps your body convert the food you eat into energy, while berberine has been researched for its ability to activate certain enzymes linked to metabolism.

When these ingredients come together, they form a trifecta that may support your body’s natural processes in multiple ways. However, individual results can vary, and it’s important to approach supplements as part of a balanced lifestyle—there’s no one-size-fits-all solution.


Why Consider the Trifecta?

The Weight Loss Trifecta isn’t a quick fix or a magic pill—it’s a combination of natural ingredients that may help support your body’s metabolic health. If you’re already focused on eating well, staying active, and managing your stress levels, adding these supplements to your routine could offer additional support. Of course, supplements aren’t meant to replace healthy habits; they’re just one piece of the puzzle.

 

Key Takeaways

The Weight Loss Trifecta—berberine, alpha lipoic acid, and white mulberry leaf extract—is a thrilling combination of natural ingredients that may help support metabolic health, energy production, and overall wellness. While they’re not a cure-all, they might just be the extra boost you’re looking for in your journey toward your goals. 

What form of these ingredients do I recommend?

If you want the doses used in the studies, and with predictable, quality plant extracts that perform time and time again, then look for the metabolic duo of Metabolic Protect and Carb Metabolic. These 2 supplements contain these 3 ingredients in precisely the doses you need. Carb Metabolic is separate so that it can easily be taken before meals as a delicious gummy. 

Most other herbal supplements on the market don’t use the right part of the plant (flowers vs stems vs petals, etc.), don’t use a predictable precision extract concentration, and don’t use the right doses. That’s why it’s critical not to just look for ingredient names but research the quality behind it. 

Check out Metabolic Protect and Carb Metabolic today. 


References

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Wei X, Li X, Chen Y, et al. Effects of berberine on metabolic syndrome in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. J Ethnopharmacol. 2021;271:113866. doi:10.1016/j.jep.2021.113866.

Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: A systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654. doi:10.1155/2012/591654.

Hsu WH, Hsieh MH, Wang CJ, et al. Mulberry leaf polyphenols and their potential effects against obesity-associated metabolic syndrome. Int J Mol Sci. 2021;22(13):6946. doi:10.3390/ijms22136946.

Stohs SJ, Preuss HG, Shara M. A review of the efficacy and safety of mulberry leaf (Morus alba L.) extracts. Phytother Res. 2012;26(3):317-325. doi:10.1002/ptr.3693.

Sudheesh S, Ajith TA, Janardhanan KK. Effect of α-lipoic acid supplementation on oxidative stress and metabolic disorders in high-fat diet-fed rats. Clin Exp Pharmacol Physiol. 2011;38(8):540-546. doi:10.1111/j.1440-1681.2011.05528.x.

Kim H, Kim MJ, Seo YR. α-Lipoic acid's anti-obesity effects: A systematic review and meta-analysis. Obes Rev. 2021;22(8)
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Mohammadi S, Saidur R, Rahim NA. The application of α-lipoic acid in obesity treatment: A review of clinical trials. Curr Obes Rep. 2017;6(3):248-259. doi:10.1007/s13679-017-0272-y.

Zhang Z, Zhang Y, Li Y, et al. Anti-obesity effect of mulberry leaf polysaccharides in high-fat diet-fed mice through promoting insulin resistance improvement and gut microbiota modulation. Nutrients. 2019;11(3):612. doi:10.3390/nu11030612.

Seo Y, Choi J, Jeong SH, Yoo HH. Hypoglycemic and anti-obesity effects of the white mulberry leaf extract in db/db mice with type 2 diabetes mellitus. J Korean Soc Food Sci Nutr. 2015;44(2):291-297. doi:10.3746/jkfn.2015.44.2.291.

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